domingo, 10 de janeiro de 2016

ESTUDO DIRIGIDO 4 - AMOXICILINA

Grupo dos beta-lactâmicos - São uma classe ampla de antibióticos, que inclui a penicilina e seus derivados, que possuem o núcleo β-lactâmico em sua estrutura molecular. É o grupo mais usado de antibióticos.

Tem um amplo espectro de atividade antibacteriana contra muitos microrganismos Gram-positivos e Gram-negativos, agindo através da inibição da biossíntese do mucopeptídeo das paredes das células das bactérias. Tem rápida ação bactericida e o mesmo perfil de segurança do grupo das penicilinas.

Formas farmacêuticas: cápsula oral, pó para suspensão oral, comprimido oral, comprimido para mastigar, comprimidos orais de liberação estendida. 

USO

A amoxicilina é um antibiótico de amplo espectro. É usado para tratar vários tipos de infecção causada por bactérias, tais como tonsilite (amidalite – infecção das amidalas), bronquite, pneumonia, gonorreia, e infecções do ouvido, nariz, garganta, pele, ou do trato urinário.Também é usada em conjunto com outro antibiótico chamado Claritromicina, para tratar úlceras causadas pela infecção por Helicobacter pylori

A administração oral, geralmente segue o esquema de doses de três vezes ao dia, alcançando altos níveis séricos e a sua eliminação é via renal. 

CEPAS SENSÍVEIS A AMOXICILINA 

Gram-positivos
Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Staphylococcus aureus sensível à penicilina, espécies de Corynebacterium, Bacillus anthracis, Listeria monocytogenes. 

Gram-negativos
Haemophilus influenzae, Escherichia coli, Proteus mirabilis, espécies de Salmonella, espécies de Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, Vibrio cholerae, H. pylori.



ALGUMAS INTERAÇÕES 

Interação GRAVE: metotrexato (antitumoral) ↔ amoxicilina

Amoxicilina, especialmente quando administrados em dosagens elevadas para infecções graves, pode aumentar os níveis sanguíneos e efeitos de metotrexato. Pode também aumentar as reações adversas, como náuseas, vômitos, úlceras na boca, e baixa contagem de células do sangue, o que pode tornar o paciente mais propenso a desenvolver anemia, problemas de sangramento e infecções.

Interação MODERADA: amoxicilina ↔ etinilestradiol/levonorgestrel (hormônios que entram na composição de anticoncepcionais)

Alguns antibióticos, como amoxicilina, podem reduzir os efeitos de etinilestradiol em algumas mulheres, podendo aumentar o risco de gravidez indesejada e sangramento de escape.

Interação MODERADA: amoxicilina↔ doxiciclina (antibiótico de amplo espectro, da classe das tetraciclinas)

Combinando estes medicamentos podem reduzir a eficácia da amoxicilina.

Beta-lactâmicos ↔ disfunção renal
A maioria dos antibióticos beta-lactâmicos são eliminados pelos rins como fármaco inalterado e, em alguns casos, também na forma de metabolitos. As concentrações séricas de antibióticos beta-lactâmicos e seus metabólitos pode ser aumentada e as meias-vidas prolongada em doentes com insuficiência renal. O ajuste da dosagem pode ser necessário e modificações devem basear-se no grau de insuficiência renal, bem como na gravidade da infecção.

E a associação de Amoxicilina com ácido clavulânico? 


É o antibiótico betalactâmico associado a um inibidor das betalactamases.
A combinação de amoxicilina com clavulanato de potássio (sal do ácido clavulânico) permite o tratamento de infecções por bactérias que resistem à amoxicilina, por produzir beta-lactamases.
O clavulanato de potássio inibe de forma irreversível as beta-lactamases e não possui atividade antibacteriana. 

NOTIFICAÇÃO
Você sabia que quando você toma um medicamento e tem uma reação adversa (uma resposta indesejada do seu corpo ao medicamento) você deve notificar, ou seja, comunicar a ANVISA ou a um Centro de Farmacovigilância?
Essa atitude é muito importante, pois a indústria que produz o remédio vai passar a ter conhecimento do que este está causando no paciente, e se irá retirar o medicamento do mercado ou não, caso o número de reações estejam aumentando (o que mostra que ele está causando mal a nós e não resolvendo nosso problema de saúde).
O mesmo deve ser feito quando você compra, por exemplo, uma caixinha de medicamentos e um deles vem quebrado ou com uma cor diferente.
Conheça o CEFAL (Centro de Farmacovigilância da Universidade Federal de Alfenas) e um pouco mais sobre a notificação.
Notifique!


Fontes
Drugs.com
Bulário online 

26 comentários:

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  3. hello I’m from USA , I have been suffering from HERPES virus for the past 3 years and i had constant pain especially in my knees, During the first year I had faith in God that i will be healed someday, but this disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came in search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of so many people who has been healed from Hepatitis B, HIV/AID, Diabetes,HSV, ALS HPV and Cancer by this Man called Dr, Aire and he also gave the email address of this man and advice we should contact him for any sickness that he would be of help, so i wrote to Dr. Aire telling him about my HERPES Virus he told me not to worry that i will be cured from this deadly disease i never believed it, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as the Doctor assured me that i will be cured,after some time i went to my medical doctor to confirmed if i have be finally cured behold it was true,and now i’m cure totally with Dr.Aire, So friends my advise is if you have such sickness or any other at all you can email Dr,Aire on this email; drairehome@gmail.com or add him up on what-app +2347036740271

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  13. i want to inform the public how i was cured of HERPES Simplex Virus by a
    Doctor called Dr.DADA. i visited different hospital but they gave me list
    of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat
    the symptoms and never cured me. I was browsing through the Internet
    searching for remedy on HERPES and i saw comment of people talking about
    how Doctor DADA cured them. I Was scared because i never believed in the
    Internet but i was convince to give him a try because i was having no hope
    of been cured of HERPES so i decided to contact him on his email, i
    searched his email on net and i saw a lot of people testifying about his
    goodness. when i contacted him he gave me hope and send a Herbal medicine
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    his Email: (drdadaspellhome7@gmail.com) OR (drdadaspellhome@hotmail.com) whatsappl him +2348158568638 and get all
    your problem solved.
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    4)Pregnancy problem
    5)Financial problem and Job promotion
    6)To get a good and rich life partner
    7)To Lose your wath
    8)to enlargement of pennis .......

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    Respostas
    1. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

      Or Cell Whatsapp Number +2348101755322 thank you

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  16. Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.Ehiaguna the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.Ehiaguna write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.Ehiaguna instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drehiaguna@gmail.com or you can also WhatsApp him +2348073908953. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

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    Respostas
    1. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

      Or Cell Whatsapp Number +2348101755322 thank you

      Eliminar
  17. Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.Ehiaguna the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.Ehiaguna write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.Ehiaguna instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drehiaguna@gmail.com or you can also WhatsApp him +2348073908953. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

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  18. Good evening to you all I want to write a shortly message to the world how doctor ehiaguna help with his great herbal medicine to cured me from this horrible virus HSV 1 and 2 I get his email from someone name Olivia mason how she was also cured by doctor ehiaguna I never believe there was cure until I meet her testimony, I contacted doctor ehiaguna I don’t believe there was cure well I am so happy to write this testimony to the world, this man immediately when I sent him email and this man response within 20 minus and give me the necessary process and the herbal was sent to within 4 day I took it according to the instruction so with 2 week I was completely cured and I get my test done I was confirm negative I am so happy if you want to get his contact you can message him with this email drehiaguna@gmail.com or you can also WhatsApp him +2348073908953 he can fix this.HIV.HEPATITIS.ANTHRAX.HPV.CANCER.ALSAND ALSO SOLVE YOUR RELATIONSHIP PROBLEM

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  19. Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.Ehiaguna the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.Ehiaguna write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.Ehiaguna instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drehiaguna@gmail.com or you can also WhatsApp him +2348073908953. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

    ResponderEliminar
  20. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you

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  21. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you

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  22. Olá a todos Este é um grande testemunho que eu devo compartilhar. Como o Dr. Ogala salvou a mim e ao meu irmão da doença do herpes, resolve um problema sério e cura qualquer doença. Dr. Ogala me curou minhas herpes em menos de uma semana depois de tentar por anos, ele é ótimo e realmente sabe o que está fazendo. Eu obriguo todo mundo. Este lançador de feitiços é muito, muito bom. Profissional, preciso, sincero e muito experiente. Obrigado pelo trabalho! Agradeço ao meu amigo por me informar do seu site. Preciso falar com você sobre meus problemas. Eu não esperava resultados instantâneos e eu estava pronto para esperar alguns meses. Para minha surpresa e espanto, comecei a ver resultados depois de alguns dias de mamilo. Meu irmão foi diagnosticado com vírus herpes, Ele resolveu todas as formas possíveis para obter a cura, mas todo o esforço acabou sendo abortado, mas depois que servimos o Dr. Ogala, que preparou ervas medicinais para curar todos os tipos de doenças (Herpes), ele enviou ervas medicinais para o vírus herpes através do serviço de correio, e deu-lhe instruções passo-a-passo sobre como aplicá-lo, quando meu irmão aplicou como indicado que ele estava totalmente curado do vírus dentro de 3 semanas de uso, nós realmente somos ótimos. Ogala é altamente recomendado. Essa é a coisa real. Tente e você não vai se decepcionar! VOCÊ PRECISA DE AJUDA? Entre em contato com 2347061120360 ou e-mail: Drogalaspells@gmail.com

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  23. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or his Email:Oyaguherbalhome@gmail.com

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  24. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or his Email:Oyaguherbalhome@gmail.com

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