terça-feira, 12 de julho de 2016

ESTUDO DIRIGIDO: IBUPROFENO

USO

O Ibuprofeno é um medicamento da classe dos antiinflamatórios não esteróides (AINES), NÃO SELETIVO, com ações antitérmicas (contra febre), analgésicas (contra dor) e antiinflamatórias. O ibuprofeno é indicado para uma série de condições, principalmente para casos de dor de origem inflamatória, como artrites, dores traumáticas, inflamações dentárias, cólicas menstruais, entre outros..
O início de ação ocorre de 15 a 30 minutos após sua administração oral e permanece por 4 a 6 horas.

O ibuprofeno já é vendido como medicação genérica, sendo muito fácil encontrá-lo nas farmácias. Em relação aos nomes comerciais disponíveis no mercado, os principias são: Advil, Alivium, Buscofen, Dalsy, Motrin, Spidufen, sob a forma de gotas, comprimidos ou como suspensão oral. 


Não se deve utilizar o ibuprofeno concomitante com bebidas alcoólicas e o Ibuprofeno é contraindicado a pacientes com úlcera gastroduodenal ou sangramento gastrintestinal e para menores de 6 meses de idade.

MECANISMO DE AÇÃO

Ibuprofeno é um derivado do ácido fenilpropiônico, inibidor da síntese das prostaglandinas, tendo propriedades analgésicas e antipiréticas. Os analgésicos antiinflamatórios não-esteróides inibem a enzima ciclooxigenase, diminuindo a formação de precursores das prostaglandinas e dos tromboxanos a partir do ácido araquidônico, diminuindo a ação destes mediadores no termostato hipotalâmico e nos receptores de dor (nociceptores).


Observação: Nota-se que a COX 1 tem um papel fisiológico no nosso organismo, uma vez que uma de suas funções é a produção do muco protetor do trato gastrointestinal. 
Como foi visto acima, o ibuprofeno é um medicamento que possui ação NÃO seletiva para COX, ou seja, ele não era inibir apenas a COX 2 que está envolvida no processo da inflamação, mas também a COX 1, que é fisiológica. 
Portanto,  nesse contexto, não é recomendado o uso desse medicamento por pacientes que possuem problemas estomacais, porque poderá ser prejudicial para o paciente. 

Propriedades farmacocinéticas – O ibuprofeno apresenta boa absorção oral, com aproximadamente 80% da dose absorvida no trato gastrintestinal, havendo diferença quando a administração é feita em jejum ou após refeição, pois a presença de alimentos diminui a absorção.


INTERAÇÕES MEDICAMENTOSA

- Interações medicamento-medicamento

O uso de ibuprofeno e de outros analgésicos e antipiréticos junto com os seguintes fármacos, deve ser evitado, especialmente nos casos de administração continua: ácido acetilsalicílico, paracetamol, colchicina, iodetos, medicamentos fotossensibilizantes, outros antiinflamatórios não esteroides, corticosteroides, antidiabéticos orais ou insulina, anti-hipertensivos e diuréticos, lítio, agentes anticoagulantes ou trombolíticos, inibidores de agregação plaquetária, digoxina, metotrexato e hormônios tireoidianos.

- Interações medicamento-exame laboratorial

Durante o uso de ibuprofeno, os exames de sangue poderão indicar anemia. Se houver sangramento no aparelho digestivo devido ao uso do ibuprofeno, o exame de fezes para pesquisa de sangue oculto poderá ter resultado positivo. O valor da taxa de açúcar no sangue (glicemia) poderá vir mais baixo durante o uso de ibuprofeno. Não existe interferência conhecida com outros exames.

REAÇÕES ADVERSAS

As reações adversas mais comuns incluem reações de hipersensibilidade, náusea, vômito, dor epigástrica, azia, tontura e rash cutâneo. 
As reações adversas raras incluem sangramento gastrintestinal ou perfuração, nefrotoxicidade, hepatite, meningite asséptica, tontura, vertigem, síndrome de Stevens-Johnson, eritema multiforme e dermatoses.

POSOLOGIA

O ibuprofeno é habitualmente vendido nas doses de 200 mg, 400 mg e 600 mg. A dose para tratar dores de origem inflamatórias é de 400 a 800 mg de até 6 em 6 horas. Nos casos de febre a dose recomendada é de 200 mg a cada 4 horas. 
A dose diária total máxima é de 3200mg (3.2 gramas), mas o recomendado é não ultrapassar as 2400 mg por dia sem autorização médica, devido ao maior riscos de efeitos colaterais. 
O uso prolongado, por mais de 1 semana, também deve ser evitado a não que sejam ordens médicas. 
Em geral, a posologia de 400 a 600 mg, 2 a 3 vezes por dia é suficiente para controlar a maioria das dores de leve a moderada intensidade.

NOTIFICAÇÃO
Você sabia que quando você toma um medicamento e tem uma reação adversa (uma resposta indesejada do seu corpo ao medicamento) você deve notificar, ou seja, comunicar a ANVISA ou a um Centro de Farmacovigilância?
Essa atitude é muito importante, pois a indústria que produz o remédio vai passar a ter conhecimento do que este está causando no paciente, e se irá retirar o medicamento do mercado ou não, caso o número de reações estejam aumentando (o que mostra que ele está causando mal a nós e não resolvendo nosso problema de saúde).
O mesmo deve ser feito quando você compra, por exemplo, uma caixinha de medicamentos e um deles vem quebrado ou com uma cor diferente.
Conheça o CEFAL (Centro de Farmacovigilância da Universidade Federal de Alfenas) e um pouco mais sobre a notificação.
Notifique!




Referências

DRUGS.COM. Ibuprofen. Disponível em: <http://www.drugs.com/ibuprofen.html>. Acesso em: 12/07/2016.

BRASIL. Agência Nacional de Vigilância Sanitária- ANVISA. Ibuprofeno. Disponível em <http://www.anvisa.gov.br/datavisa/fila_bula/frmVisualizarBula.asp?pNuTransacao=2813342015&pIdAnexo=2545759>. Acesso em: 12/07/2016.

16 comentários:

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  2. Muito boa sua matéria e explicações sobre o remédio.
    Me ajudou a tirar umas boas dúvidas junto com esta outra pagina.
    E antes de tomar qualquer remédio é importante falar com seu médico.

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    Respostas
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  12. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

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  13. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you

    ResponderEliminar
  14. Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when i start using it in just 2weeks i was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. i knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. i discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south korean . i used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or his Email:Oyaguherbalhome@gmail.com

    ResponderEliminar